Siramesine HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1250 | Check With Us |
| 250mg | $2050 | Check With Us |
| 500mg | $3075 | Check With Us |
: Cat #: V2908 CAS #: 224177-60-0 Purity ≥ 98%
Description: Formerly known as Lu-28-179, siramesine HCl is a potent and selective sigma-2 receptor agonist with anticancer effects.
References: Cell Death Dis. 2013 Oct 3;4:e818.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 491.05 |
|---|---|
| Molecular Formula | C30H32ClFN2O |
| CAS No. | 224177-60-0 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >10 mMrr |
| Water: <1 mg/mLrr | |
| Ethanol: NA | |
| SMILES Code | FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=CC=CC=C45)C6=C2C=CC=C6)C=C1.[H]Cl |
| Synonyms | Lu-28-179; Lu 28179; Lu 28-179; Lu-28179; Lu28-179; Lu28179; Siramesine HCl; Siramesine hydrochloride; |
| Protocol | In Vitro | Siramesine hydrochloride displays the binding affinities: IC50 (sigma 1)=17 nM, IC50 (sigma 2)=0.12 nM, IC50 (5-HT1A)=21000 nM, IC50 (5-HT1A)=2000 nM, IC50 (D2)=800 nM, IC50 (alpha 1)=330 nM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0365 mL | 10.1823 mL | 20.3645 mL | 40.7290 mL |
| 5mM | 0.4073 mL | 2.0365 mL | 4.0729 mL | 8.1458 mL |
| 10mM | 0.2036 mL | 1.0182 mL | 2.0365 mL | 4.0729 mL |
| 20mM | 0.1018 mL | 0.5091 mL | 1.0182 mL | 2.0365 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.