Anavex2-73 (Anavex-273; AE-37) HCl is a novel and potent muscarinic/σ1 ( Sigma-1) ligand/agonist (IC50 = 860 nM) with therapeutic potential for treating Alzheimer’s disease.

BD1047 dihydrobromide (BD-1047) is a selective functional antagonist of sigma receptors (σ receptors) with antipsychotic activity and may be used for schizophrenia.

CT1812 (Elayta) is a novel, potent and orally bioavailable allosteric antagonist of the sigma-2 receptor complex (sigma-2/PGRMC1) that prevents and displaces binding of Aβ oligomers to neurons.

EST64454 HCl is a potent ,selective and orally active sigma-1 receptor antagonist( Ki = 22 nM).

SA4503 dihydrochloride (also known as AGY94806 dihydrochloride and Cutamesine dihydrochloride), is a potent sigma-1 (σ1) receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.

Dimemorfan phosphate (Astomin; AT17; Gentus; AT-17) is a morphinan-based sigma 1 receptor agonist with potent antitussive activity.

S1RA HCl (also known as E-52862 HCl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

PD 144418 oxalate is a novel, high affinity, highly potent and specific sigma 1 (σ1) receptor ligand with Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively.

S1RA HCl (also known as E-52862 HCl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

Siramesine (Formerly known as Lu-28-179) is a potent and selective agonist of sigma-2 receptor.