Sinomenine (Cucoline)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $250 | Check With Us |
| 5g | $450 | Check With Us |
| 10g | $675 | Check With Us |
: Cat #: V1755 CAS #: 568-72-9 Purity ≥ 98%
Description: Sinomenine (Coculine; Cucoline; Kukoline) is a naturally occuring alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China.
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| Molecular Weight (MW) | 329.39 |
|---|---|
| Molecular Formula | C19H23NO4 |
| CAS No. | 568-72-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Synonyms | Coculine; Cucoline; Kukoline |
| Protocol | In Vitro | Tanshinone IIA is one of the most abundant components in Salvia miltiorrhiza root, protecting rat myocardium-derived H9C2 cells from apoptosis. Treatment of H9C2 cells with Tanshinone IIA inhibits angiotensin II-induced apoptosis by downregulating the expression of PTEN (phosphatase and tension protein homologers), a tumor suppressor that plays a key role in apoptosis. Tanshinone IIA inhibits angiotensin II (AngII)-induced apoptosis by downregulating the expression of phosphatase and tension protein homologs (PTEN). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0359 mL | 15.1796 mL | 30.3591 mL | 60.7183 mL |
| 5mM | 0.6072 mL | 3.0359 mL | 6.0718 mL | 12.1437 mL |
| 10mM | 0.3036 mL | 1.5180 mL | 3.0359 mL | 6.0718 mL |
| 20mM | 0.1518 mL | 0.7590 mL | 1.5180 mL | 3.0359 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.