Simvastatin | CAS 79902-63-9

Simvastatin

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$390	In Stock
2g	$590	In Stock
5g	$995	In Stock

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Cat #: V0924 CAS #: 79902-63-9 Purity ≥ 98%

Description: Simvastatin (MK0733, Zocor; Synvinolin; Sinvacor; MK-0733; SIM), a marketed anti-hyperlipidemic drug of the statin class, is a lactone prodrug that has to be activated through hydrolysis to the active β-hydroxy acid form, which then acts as a potent and competitive inhibitor of HMG-CoA (3-hydroxy-3-methyl glutaryl coenzyme A) reductase with Ki of 0.1-0.2 nM in cell-free assays.

References: Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	418.57
Molecular Formula	C25H38O5
CAS No.	79902-63-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 83 mg/mL (198.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 83 mg/mL (198.3 mM)
Solubility In Vivo	2% DMSO+30% PEG 300+5% Tween80+ddH2O: 10 mg/mL
SMILES Code	C[C@H]1C=CC2=C[C@H](C)C[C@H](OC(C(C)(C)CC)=O)C2[C@H]1CC[C@@H]3C[C@@H](O)CC(O3)=O
Synonyms	MK-0733, MK 0733, MK0733, Zocor; Synvinolin; MK 733; Sinvacor; MK-733; MK733; Simvastatin;

Protocol	In Vitro	Simvastatin suppresses cholesterol synthesis in mouse L-M cell, rat H4II E cell, and human Hep G2 cell with IC50s of 19.3 nM, 13.3 nM and 15.6 nM, respectively. Simvastatin is an inactive drug precursor that has no drug activity itself and must be metabolized into its hydroxy acid form in the liver to function. In vitro experiments, it can be activated by sodium hydroxide (NaOH).
Protocol	In Vivo	Simvastatin suppresses the conversion of radiolabeled acetate to cholesterol with an IC50 of 0.2 mg/kg via p.o. administration.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3891 mL	11.9454 mL	23.8909 mL	47.7817 mL
5mM	0.4778 mL	2.3891 mL	4.7782 mL	9.5563 mL
10mM	0.2389 mL	1.1945 mL	2.3891 mL	4.7782 mL
20mM	0.1195 mL	0.5973 mL	1.1945 mL	2.3891 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.