Shikonin (C.I.-75535; Isoarnebin 4)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $420 | Check With Us |
| 1g | $750 | Check With Us |
| 5g | $2025 | Check With Us |
: Cat #: V14729 CAS #: 517-89-5 Purity ≥ 99%
Description: Shikonin (C.I. 75535; Isoarnebin 4) is a natural product and major component of the Chinese medicin 'zicao' with various biological activities such as anti-inflammatory activity by inhibition of TNF-α, NF-κB, HIV-1.
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| Molecular Weight (MW) | 288.3 |
|---|---|
| Molecular Formula | C16H16O5 |
| CAS No. | 517-89-5 |
| Synonyms | Tokyo Violet |
| Protocol | In Vitro | Treatments of Shikonin at 5 and 7.5 μM significantly inhibit the cell viability starting from 12 h and the inhibitory effects are presented in time-dependent patterns compare with the 0 h group in both cell lines. It is found that 5 μM Shikonin displays greater inhibition compare to 2.5 μM at the time points from 24 to 48 h. The invasiveness of U87 and U251 cells is significantly attenuated when treated with Shikonin at 2.5, 5, and 7.5 μM compare with the control group at 24 and 48 h (p<0.01) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4686 mL | 17.3430 mL | 34.6861 mL | 69.3722 mL |
| 5mM | 0.6937 mL | 3.4686 mL | 6.9372 mL | 13.8744 mL |
| 10mM | 0.3469 mL | 1.7343 mL | 3.4686 mL | 6.9372 mL |
| 20mM | 0.1734 mL | 0.8672 mL | 1.7343 mL | 3.4686 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.