SEP-363856 HCl (Ulotaront)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1250 | Check With Us |
| 250mg | $1950 | Check With Us |
| 500mg | $2925 | Check With Us |
: Cat #: V2291 CAS #: 1310422-41-3 (HCl) Purity ≥ 98%
Description: SEP-363856 HCL (also known as Ulotaront; SEP363856; SEP-856 HCL), is a novel and potent orally bioactive trace amine-associated receptor 1 (TAAR1) agonist with serotonin 1A (5-HT1A) agonist activity.
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- Related Biological Data
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| Molecular Weight (MW) | 219.73 |
|---|---|
| Molecular Formula | C9H14ClNOS |
| CAS No. | 1310422-41-3 (HCl) |
| Protocol | In Vitro | SEP-856 (10 μM) shows >50% inhibition of specific binding at α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors |
|---|---|---|
| In Vivo | SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs | |
| Animal model | Acute treatment with phencyclidine (PCP), which induces robust hyperactivity in rodents | |
| Dosages | Acute treatment with phencyclidine (PCP), which induces robust hyperactivity in rodents | |
| Administration | Orally once. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.5510 mL | 22.7552 mL | 45.5104 mL | 91.0208 mL |
| 5mM | 0.9102 mL | 4.5510 mL | 9.1021 mL | 18.2042 mL |
| 10mM | 0.4551 mL | 2.2755 mL | 4.5510 mL | 9.1021 mL |
| 20mM | 0.2276 mL | 1.1378 mL | 2.2755 mL | 4.5510 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.