Scopoletin (Gelseminic acid; Chrysatropic acid)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $250 | Check With Us |
| 1g | $375 | Check With Us |
| 5g | $1125 | Check With Us |
: Cat #: V28743 CAS #: 92-61-5 Purity ≥ 99%
Description: Scopoletin (Gelseminic acid; Chrysatropic acid) is a naturally occurring coumarin acting as an inhibitor of acetylcholinesterase (AChE), has anti-hyperuricemic effect.
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| Molecular Weight (MW) | 192.17 |
|---|---|
| Molecular Formula | C₁₀H₈O₄ |
| CAS No. | 92-61-5 |
| SMILES Code | O=C1C=CC2=CC(OC)=C(O)C=C2O1 |
| Protocol | In Vitro | Scopoletin (SCT) is identified as a putative inhibitor of acetylcholinesterase (AChE). Scopoletin enhances the K+-stimulated release of ACh from rat frontal cortex synaptosomes, showing a bell-shaped dose effect curve (Emax: 4 μM) |
|---|---|---|
| In Vivo | Scopoletin (2 μg, i.c.v.) increases T-maze alternation and ameliorated novel object recognition of mice with scopolamine-induced cholinergic deficit. It also reduces age-associated deficits in object memory of 15-18-month-old mice (2 mg/kg sc). Mice injected with 2 μg Scopoletin show an increased alternation rate of 71.3±2.5% |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.2037 mL | 26.0186 mL | 52.0373 mL | 104.0745 mL |
| 5mM | 1.0407 mL | 5.2037 mL | 10.4075 mL | 20.8149 mL |
| 10mM | 0.5204 mL | 2.6019 mL | 5.2037 mL | 10.4075 mL |
| 20mM | 0.2602 mL | 1.3009 mL | 2.6019 mL | 5.2037 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.