SC144 hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | Check With Us |
| 250mg | $850 | Check With Us |
| 500mg | $1275 | Check With Us |
: Cat #: V28778 CAS #: 917497-70-2 Purity ≥ 99%
Description: SC144 hydrochloride (HCl) is a first-in-class, potent and orally bioavailable small-molecule gp130 inhibitor; it inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 in a submicromolar range.
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| Molecular Weight (MW) | 358.76 |
|---|---|
| Molecular Formula | C16H12ClFN6O |
| CAS No. | 917497-70-2 |
| SMILES Code | O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3.[H]Cl |
| Synonyms | SC144 hydrochloride, SC144 HCl |
| Protocol | In Vitro | SC144 is cytotoxic to ovarian cancer cells via a mechanism involving the inhibition of gp130 activity, leading to the inactivation of Akt and Stat3 as well as the suppression of Stat3-regulated gene expression. As are result, SC144 treatment eventually causes cell-cycle arrest, anti-angiogenesis, and apoptosis. SC144 (0.5-2 μM; 0-6 hours) substantially increases the phosphorylation of gp130 (S782) in both OVCAR-8 and Caov-3 cells in a time- and dose-dependent manner. SC144 (2 μM; 24 hours) causes significantly more apoptosis in OVCAR-8 and Caov-3 than normal kidney epithelial and normal endometrial cells. The potency of SC144 toward NCI/ADR-RES (Paclitaxel- and Doxorubicin-resistant, IC50=0.43 μM) and HEY (Cisplatin-resistant, IC50=0.88 μM) suggests an ability to overcome drug resistance in ovarian cancer. SC144 inhibits cell growth in a panel of human ovarian cancer cell lines with IC50s in a submicromolar range (IC50=OVCAR-8, OVCAR-5, OVCAR-3= 0.72, 0.49, 0.95 μM). |
|---|---|---|
| In Vivo | SC144 (100 mg/kg; p.o.; daily for 35 days) treatment shows the average tumor volume in mice 82% smaller than that in the control group. SC144 (10 mg/kg; i.p.; daily for 58 days) suppresses tumor growth in human ovariancancer xenografts. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7874 mL | 13.9369 mL | 27.8738 mL | 55.7476 mL |
| 5mM | 0.5575 mL | 2.7874 mL | 5.5748 mL | 11.1495 mL |
| 10mM | 0.2787 mL | 1.3937 mL | 2.7874 mL | 5.5748 mL |
| 20mM | 0.1394 mL | 0.6968 mL | 1.3937 mL | 2.7874 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
+
%ddH2O
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.