SBP-7455
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | Check With Us |
| 500mg | $2160 | Check With Us |
| 1g | $3240 | Check With Us |
: Cat #: V2248 CAS #: 1884222-74-5 Purity ≥ 99%
Description: SBP-7455 is a potent dual inhibitors of ULK1 and ULK2 (ULK1/2),It potently inhibited ULK1/2 enzymatic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 354.33 |
|---|---|
| Molecular Formula | C16H17F3N4O2 |
| CAS No. | 1884222-74-5 |
| SMILES Code | COC1=C(OC)C=CC(NC2=NC(NC3CC3)=C(C(F)(F)F)C=N2)=C1 |
| Synonyms | SBP-7455; SBP7455; SBP 7455; |
| Protocol | In Vitro | SBP-7455 (compound 26; 72 h) treatment inhibits cell growth with an IC50 of 0.3 μM for MDA-MB-468 cells. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells that are dependent on autophagy for survival. |
|---|---|---|
| In Vivo | A single dose of SBP-7455 (compound 26) (30 mg/kg) is orally administered to mice. The Tmax for SBP-7455 is approximately 1 h, the Cmax is 990 nM and the T1/2 is 1.7 h. The plasma concentration of SBP-7455 remains above the ULK1 IC50 for almost 4 h after oral dosing. The mice are dosed with SBP-7455 (compound 26) (10 mg/kg) by oral gavage, and liver samples were collected after 2 h. The results reveals robust inhibition of pATG13 (Ser318), as well as downregulation of total ATG13 and ULK1 levels by SBP-7455. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8222 mL | 14.1111 mL | 28.2223 mL | 56.4446 mL |
| 5mM | 0.5644 mL | 2.8222 mL | 5.6445 mL | 11.2889 mL |
| 10mM | 0.2822 mL | 1.4111 mL | 2.8222 mL | 5.6445 mL |
| 20mM | 0.1411 mL | 0.7056 mL | 1.4111 mL | 2.8222 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.