SB-277011 Dihydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$400	To Be Confirmed
100mg	$650	To Be Confirmed
200mg	$975	To Be Confirmed

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Cat #: V4610 CAS #: 1226917-67-4 (HCl) Purity ≥ 98%

Description: SB-277011 dihydrochloride (also known as SB-277011A diHCl) is a novel, potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0,<5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.

References: Stemp G, et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat. J Med Chem. 2000 May 4;43(9):1878-85.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	511.49
Molecular Formula	C28H32Cl2N4Or
CAS No.	1226917-67-4 (HCl)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vitro	SB-277011 dihydrochloride is an orally effective, selective brain-penetrating dopamine D3 Receptor antagonists, to D2 Receptor, 5-HT1B Receptor, 5-HT1D The receptor restores ≥100-fold selectivity for D3、D2、5-HT1B、5-HT1D The pK of the receptori 8.0, 6.0, 5.2, and 5.9, respectively
Protocol	In Vivo	SB-277011 dihydrochloride (SB 277011; 3 mg/kg, oral) completely reverses the effect of quinolan on rat nucleus accumbens, but does not reverse the effect of quinolan in the rat striatum at 93 mg/kg

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9551 mL	9.7754 mL	19.5507 mL	39.1014 mL
5mM	0.3910 mL	1.9551 mL	3.9101 mL	7.8203 mL
10mM	0.1955 mL	0.9775 mL	1.9551 mL	3.9101 mL
20mM	0.0978 mL	0.4888 mL	0.9775 mL	1.9551 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.