SAR439859
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1250 | To Be Confirmed |
| 100mg | $1875 | To Be Confirmed |
| 200mg | $2825 | To Be Confirmed |
: Cat #: V40395 CAS #: 2114339-57-8 Purity ≥ 99%
Description: Amcenestrant (SAR-439859; SAR439859) is a potent, orally available, and nonsteroidal estrogen receptor degrader (SERD) with potential anticancer activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 554.48 |
|---|---|
| Molecular Formula | C₃₁H₃₀Cl₂FNO₃ |
| CAS No. | 2114339-57-8 |
| Synonyms | SAR439859 |
| Protocol | In Vitro | SAR439859 (compound 43d) induces strong in vivo antitumor activity against a variety of BC cell lines and patient-derived xenografts, including models that harbor ERα mutations |
|---|---|---|
| In Vivo | SAR439859 (compound 43d; orally; 2.5-25 mg/kg; twice daily for 30 days) exhibits substantial tumor-growth inhibition and displays tumor regression at the dose of 25 mg/kg/BID | |
| Animal model | Nu/nu mouse with MCF7 tumor xenograft model | |
| Dosages | 2.5, 5, 12.5, 25 mg/kg | |
| Administration | Orally; twice daily for 30 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8035 mL | 9.0175 mL | 18.0349 mL | 36.0698 mL |
| 5mM | 0.3607 mL | 1.8035 mL | 3.6070 mL | 7.2140 mL |
| 10mM | 0.1803 mL | 0.9017 mL | 1.8035 mL | 3.6070 mL |
| 20mM | 0.0902 mL | 0.4509 mL | 0.9017 mL | 1.8035 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.