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Saquinavir (Ro-31-8959; Invirase; Fortovase)

This product is for research use only, not for human use. We do not sell to patients.

Saquinavir (Ro-31-8959; Invirase; Fortovase)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$950Check With Us
1g$1550Check With Us
5g$3925Check With Us
email: [email protected]        [email protected]

Cat #: V33345 CAS #: 127779-20-8 Purity ≥ 99%

Description: Saquinavir (Ro-31-8959; Invirase; Fortovase),an HIV Protease Inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.

References: Marco Donia, Danijela Maksimovic-Ivanic, Sanja Mijatovic, et al. In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells. Cell cycle. 2011, 1

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Molecular Weight (MW)670.84
Molecular FormulaC38H50N6O5
CAS No.127779-20-8
SMILES CodeCC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)N)NC(=O)c4ccc5ccccc5n
SynonymsFortovase; Saquinavir; Sch 52852; Invirase; Ro 31 8959; Ro 31-8959; Ro 31-8959/000; Ro 318959;
ProtocolIn VitroSaquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4907 mL7.4533 mL14.9067 mL29.8134 mL
5mM0.2981 mL1.4907 mL2.9813 mL5.9627 mL
10mM0.1491 mL0.7453 mL1.4907 mL2.9813 mL
20mM0.0745 mL0.3727 mL0.7453 mL1.4907 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.