Sacubitril sodium | CAS 149690-05-1 (sodium)

Sacubitril sodium

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$420	Check With Us
2g	$750	Check With Us
5g	$1265	Check With Us

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Cat #: V4541 CAS #: 149690-05-1 (sodium) Purity ≥ 98%

Description: Sacubitril sodium (also known as AHU-377), the sodium salt of Sacubitril, is an NEP (neutral endopeptidase 24.11) inhibitor (IC50 = 5 nM) used as a component of the heart failure medicine LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan).

References: Hegde, L.G., et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacol 11, P33 (2011).

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	433.47
Molecular Formula	C24H28NNaO5
CAS No.	149690-05-1 (sodium)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C([O-])CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.[Na+]
Synonyms	Sacubitril sodium; AHU377; AHU 377; AHU-377; LCZ696. Entresto

Protocol	In Vitro	Sacubitril sodium increases neprylisin-degraded peptides, such as natriuretic peptides (NPs), peptide natriuretic atrial (ANP) and peptide natriuretic brain (BNP).
Protocol	In Vivo	In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle).

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3070 mL	11.5348 mL	23.0696 mL	46.1393 mL
5mM	0.4614 mL	2.3070 mL	4.6139 mL	9.2279 mL
10mM	0.2307 mL	1.1535 mL	2.3070 mL	4.6139 mL
20mM	0.1153 mL	0.5767 mL	1.1535 mL	2.3070 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.