SA4503 dihydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $720 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V2813 CAS #: 165377-44-6 Purity ≥ 98%
Description: SA4503 dihydrochloride (also known as AGY94806 dihydrochloride and Cutamesine dihydrochloride), is a potent sigma-1 (σ1) receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
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| Molecular Weight (MW) | 441.43 |
|---|---|
| Molecular Formula | C₂₃H₃₄Cl₂N₂O₂ |
| CAS No. | 165377-44-6 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 30 mg/mLrr |
| Water: < 1 mg/mLrr | |
| Ethanol: < 1 mg/mL | |
| SMILES Code | COC1=CC=C(C=C1OC)CCN2CCN(CCCC3=CC=CC=C3)CC2.[H]Cl.[H]Cl |
| Synonyms | SA4503; SA 4503; SA-4503; AGY94806; AGY-94806; AGY 94806; Cutamesine HCl |
| Protocol | In Vitro | The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) sites in guinea pig brain homogenates |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2654 mL | 11.3268 mL | 22.6536 mL | 45.3073 mL |
| 5mM | 0.4531 mL | 2.2654 mL | 4.5307 mL | 9.0615 mL |
| 10mM | 0.2265 mL | 1.1327 mL | 2.2654 mL | 4.5307 mL |
| 20mM | 0.1133 mL | 0.5663 mL | 1.1327 mL | 2.2654 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Volume(start)
V1
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Concentration(final)
C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.