(RS)-MCPG | CAS 146669-29-6

(RS)-MCPG

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1050	Check With Us
500mg	$1650	Check With Us
1g	$2475	Check With Us

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Cat #: V3335 CAS #: 146669-29-6 Purity ≥ 98%

Description: (RS)-a-Methyl-4-carboxyphenylglycine [(RS)-MCPG] is a group I and II mGluR (metabotropic glutamate receptor) antagonist, it blocked TBS-induced shifts in both juvenile and neonatal hippocampal neurons.

References: Fiona Yeuk-Lun Choi, et al. The effects of (RS)-MCPG on amphetamine-induced sensitization in neonatal rats.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	209.20
Molecular Formula	C₁₀H₁₁NO₄
CAS No.	146669-29-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 5mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
Synonyms	alpha-MCPG; (RS)-MCPG; alpha MCPG; (RS) MCPG; alphaMCPG; (RS)MCPG

Protocol	In Vitro	MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)
Protocol	In Vivo	Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.7801 mL	23.9006 mL	47.8011 mL	95.6023 mL
5mM	0.9560 mL	4.7801 mL	9.5602 mL	19.1205 mL
10mM	0.4780 mL	2.3901 mL	4.7801 mL	9.5602 mL
20mM	0.2390 mL	1.1950 mL	2.3901 mL	4.7801 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.