FTIDC is a novel, orally bioactive, highly potent and selective negative allosteric modulator/antagonist of metabotropic glutamate receptor (mGluR) 1 with anxiolytic and antipsychotic effects.

JNJ-46778212 (also known as VU 0409551) is a novel, potent, orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulator (PAMs) with an EC50 of 260 nM.

MFZ 10-7 is a novel and potent mGluR5 antagonist.

ML-254( also known as VU-0430644 or VU0430644-2); is a novel and potent Positive Allosteric Modulators.

LY-487379 is a novel, potent and selective PAM (positive allosteric modulator) for the metabotropic glutamate receptor group II subtype mGluR2.

Basimglurant sulfate (RG7090; RO491752) is a potent, selective and orally bioavailable mGlu5 negative allosteric modulator with a Kd of 1.1 nM.

CFMTI is a novel, potent and selective allosteric antagonist of metabotropic glutamate receptor (mGluR) 1 with IC50 of 2.6 nM.

JNJ-42153605 is a potent, selective and allosteric modulator of the mGlu2 (metabotropic glutamate 2) receptor with with an EC50 of 17 nM.

AZD-9272 is a potent, selective, orally bioavailable and brain penetrant antagonist mGlu5 (metabotropic glutamate receptor 5) with IC50 values of 2.6 and 7.6 nM for rat and human receptors, respectively.

LSN-2463359 is a novel and potent PAM/positive allosteric modulator of metabotropic glutamate 5 (mGlu5).