RRx-001 (ABDNAZ)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2150 | Check With Us |
| 1g | $3225 | Check With Us |
: Cat #: V2621 CAS #: 925206-65-1 Purity ≥ 98%
Description: RRx-001 (RRx001; ABDNAZ) is a novel hypoxia-selective epigenetic modulator with potential radiosensitizing and anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 268.02 |
|---|---|
| Molecular Formula | C5H6BrN3O5 |
| CAS No. | 925206-65-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (197.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 23 mg/mL (85.8 mM) | |
| SMILES Code | O=[N+](C1([N+]([O-])=O)CN(C(CBr)=O)C1)[O-] |
| Synonyms | RRX-001; RRX 001; RRx001; ABDNAZ |
| Protocol | In Vitro | RRx-001 inhibits DNA methylation by downregulating DNA methytransferases. RRx-001 induces significant G1 phase growth arrest, with concomitant decrease in S phase. RRx-001 triggers significant apoptosis in MM cells. RRx-001 blocks migration of MM cells and associated angiogenesis. RRx-001 (0-5 μM, 24 hours) inhibits MM cells growth and overcomes resistance to novel and conventional therapies. |
|---|---|---|
| In Vivo | RRx-001 (5 mg/kg or 10 mg/kg, I.V., thrice-weekly for 24 days) inhibits tumor growth and prolongs survival in a xenograft mouse model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7311 mL | 18.6553 mL | 37.3106 mL | 74.6213 mL |
| 5mM | 0.7462 mL | 3.7311 mL | 7.4621 mL | 14.9243 mL |
| 10mM | 0.3731 mL | 1.8655 mL | 3.7311 mL | 7.4621 mL |
| 20mM | 0.1866 mL | 0.9328 mL | 1.8655 mL | 3.7311 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.