Rotigotine (N-0437; N-0923)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$750	Check With Us
500mg	$1150	Check With Us
1g	$1725	Check With Us

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Cat #: V1253 CAS #: 99755-59-6 Purity ≥ 98%

Description: Rotigotine (formerly N-0437; N-0923; N0437; N0923; trade names Neupro among others) is a potent, non-selective full agonist of dopamine receptor that has been approved for use in the treatment of PD/Parkinson's disease and restless legs syndrome.

References: Bertaina-Anglade V, et, al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24;548(1-3):106-14.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	315.47
Molecular Formula	C19H25NOS
CAS No.	99755-59-6
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 63 mg/mL (199.7 mM)rr
	Water: <1 mg/mLrr
	Ethanol: 63 mg/mL (199.7 mM)
Synonyms	N0923, N-0923, N 0923

Protocol	In Vivo	Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect
	Animal model	Male Sprague–Dawley rats
	Dosages	0.1, 0.5, 1, and 5 mg/kg
	Administration	Subcutaneous injection; for 14 days.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1699 mL	15.8494 mL	31.6987 mL	63.3975 mL
5mM	0.6340 mL	3.1699 mL	6.3397 mL	12.6795 mL
10mM	0.3170 mL	1.5849 mL	3.1699 mL	6.3397 mL
20mM	0.1585 mL	0.7925 mL	1.5849 mL	3.1699 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.