Rosuvastatin Calcium

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$250	Check With Us
5g	$450	Check With Us
10g	$675	Check With Us

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Cat #: V0925 CAS #: 147098-20-2 Purity ≥ 99%

Description: Rosuvastatin Calcium (S-4522, Rosuvastatin hemicalcium; ZD-4522; ZD4522, trade name: Crestor), a member of the statin class of lipid-lowering drugs, is a potent and competitive inhibitor of HMG-CoA reductase with potential anti-hyperlipidemic activity.

References: Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	500.57
Molecular Formula	C22H28FN3O6S.1/2Ca
CAS No.	147098-20-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (199.8 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	4% DMSO+30% PEG 300+dd H2O: 10 mg/mL
SMILES Code	CC(C1=NC(=NC(=C1/C=C/C(O)CC(O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC (=C1/C=C/C(O)CC(O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]
Synonyms	ZD 4522; Rosuvastatin calcium; S-4522; Rosuvastatin hemicalcium; ZD-4522; ZD4522; S 4522; S4522; ZD 4522 calcium salt; ZD 4522 Calcium; Brand name: Crestor.

Protocol	In Vivo	Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9977 mL	9.9886 mL	19.9772 mL	39.9545 mL
5mM	0.3995 mL	1.9977 mL	3.9954 mL	7.9909 mL
10mM	0.1998 mL	0.9989 mL	1.9977 mL	3.9954 mL
20mM	0.0999 mL	0.4994 mL	0.9989 mL	1.9977 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.