Ropinirole (SKF-101468)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $480 | Check With Us |
| 1g | $820 | Check With Us |
| 5g | $2214 | Check With Us |
: Cat #: V8750 CAS #: 91374-21-9 Purity ≥ 99%
Description: Ropinirole (also known as AS-041164; SKF101468; Requip) a potent and selective dopamine D2 receptors agonist (Ki = 29 nM) of the non-ergoline class of medications with anti-PD effects.
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- Related Biological Data
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| Molecular Weight (MW) | 260.37 |
|---|---|
| Molecular Formula | C16H24N2O |
| CAS No. | 91374-21-9 |
| Protocol | In Vitro | Ropinirole has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors |
|---|---|---|
| In Vivo | Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8407 mL | 19.2034 mL | 38.4069 mL | 76.8138 mL |
| 5mM | 0.7681 mL | 3.8407 mL | 7.6814 mL | 15.3628 mL |
| 10mM | 0.3841 mL | 1.9203 mL | 3.8407 mL | 7.6814 mL |
| 20mM | 0.1920 mL | 0.9602 mL | 1.9203 mL | 3.8407 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
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Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.