Ro 67-7476
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1200 | Check With Us |
| 500mg | $1700 | Check With Us |
| 1g | $2550 | Check With Us |
: Cat #: V3342 CAS #: 298690-60-5 Purity ≥ 98%
Description: Ro 67-7476 is a novel and selective positive allosteric modulator of mGlu1 receptors.
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| Molecular Weight (MW) | 319.39 |
|---|---|
| Molecular Formula | C17H18FNO2S |
| CAS No. | 298690-60-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 40 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=S(N1C(C2=CC=C(F)C=C2)CCC1)(C3=CC=C(C)C=C3)=O |
| Synonyms | Ro 67-7476; Ro-67-7476; Ro 67-7476 |
| Protocol | In Vitro | In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1310 mL | 15.6548 mL | 31.3097 mL | 62.6194 mL |
| 5mM | 0.6262 mL | 3.1310 mL | 6.2619 mL | 12.5239 mL |
| 10mM | 0.3131 mL | 1.5655 mL | 3.1310 mL | 6.2619 mL |
| 20mM | 0.1565 mL | 0.7827 mL | 1.5655 mL | 3.1310 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.