Ro 61-8048

This product is for research use only, not for human use. We do not sell to patients.

Ro 61-8048
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Size Price Stock
500mg$750Check With Us
1g$1250Check With Us
5g$3165Check With Us

Cat #: V2876 CAS #: 199666-03-0 Purity ≥ 99%

Description: Ro 61-8048 (Ro-618048) is a novel, high-affinity, oral, potent and selective kynurenine hydroxylase inhibitor (IC50 = 37 nM) with anti-dyskinesia activity.

References: S Röver, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85.

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Molecular Weight (MW)421.45
Molecular FormulaC17H15N3O6S2
CAS No.199666-03-0
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 59 mg/mLr
Water: <1 mg/mLr
Ethanol: NA
SMILES CodeO=S(C1=CC=C(OC)C(OC)=C1)(NC2=NC(C3=CC=CC([N+]([O-])=O)=C3)=CS2)=O
SynonymsRo 61-8048; Ro-61-8048; Ro61-8048; Ro618048; Ro 618048; Ro-618048.
ProtocolIn VitroIn gerbils, a dose of 30 µmol/kg po (12.64 µg/kg Ro 61-8048, compound 16) leads to inhibition of the cerebral enzyme which peaked after 2h (∼85% inhibition) and persisted for up to 8 h.
In VivoRo 61-8048 (50, 100 and 150 mg/kg i.p.) significantly reduces the severity of dystonia in dtsz hamsters without leading to marked central side effects.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3728 mL11.8638 mL23.7276 mL47.4552 mL
5mM0.4746 mL2.3728 mL4.7455 mL9.4910 mL
10mM0.2373 mL1.1864 mL2.3728 mL4.7455 mL
20mM0.1186 mL0.5932 mL1.1864 mL2.3728 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
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Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.