Ro 363 | CAS 74513-77-2

Ro 363

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50mg	$850	Check With Us
100mg	$1275	Check With Us
200mg	$1910	Check With Us

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Cat #: V5976 CAS #: 74513-77-2 Purity ≥ 98%

Description: Ro 363 is a potent and selective beta 1-adrenoceptor agonist and an effective inotropic stimulant, as well as a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility.

References: Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimit

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	363.41
Molecular Formula	C19H25NO6
CAS No.	74513-77-2
SMILES Code	OC1=CC=C(OCC(O)CNCCC2=CC=C(OC)C(OC)=C2)C=C1O;
Synonyms	Ro363; Ro-363; Ro 363

Protocol	In Vitro	Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses
Protocol	In Vivo	In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7517 mL	13.7586 mL	27.5171 mL	55.0343 mL
5mM	0.5503 mL	2.7517 mL	5.5034 mL	11.0069 mL
10mM	0.2752 mL	1.3759 mL	2.7517 mL	5.5034 mL
20mM	0.1376 mL	0.6879 mL	1.3759 mL	2.7517 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.