Ro 08-2750
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2250 | Check With Us |
| 1g | $3375 | Check With Us |
: Cat #: V6190 CAS #: 37854-59-4 Purity ≥ 98%
Description: Ro 08-2750 is a novel, potent, selective, and reversible non-peptide inhibitor of Nerve growth factor (NGF), binding to the NGF dimer with a KD of ~ 1 μM.
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| Molecular Weight (MW) | 270.24 |
|---|---|
| Molecular Formula | C13H10N4O3 |
| CAS No. | 37854-59-4 |
| SMILES Code | O=CC1=C(C)C=C2N=C3C(NC(N=C3N(C)C2=C1)=O)=O |
| Synonyms | Ro 082750; Ro -082750; Ro082750; Ro 08-2750; Ro08-2750; Ro-08-2750; |
| Protocol | In Vitro | Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7004 mL | 18.5021 mL | 37.0041 mL | 74.0083 mL |
| 5mM | 0.7401 mL | 3.7004 mL | 7.4008 mL | 14.8017 mL |
| 10mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 7.4008 mL |
| 20mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 3.7004 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.