Rivastigmine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $400 | Check With Us |
| 5g | $700 | Check With Us |
| 10g | $1050 | Check With Us |
: Cat #: V33475 CAS #: 123441-03-2 Purity ≥ 99%
Description: Rivastigmine, also known as ENA-713 and SDZ-ENA 713, is a reversible cholinesterase inhibitor with IC50 of 5.5 μM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 250.34 |
|---|---|
| Molecular Formula | C₁₄H₂₂N₂O₂; |
| CAS No. | 123441-03-2 |
| Protocol | In Vitro | Rivastigmine (S-Rivastigmine; 1 µM; 24 hours) reduces LPS (2.5 µg/ml)-induced TNF-α and IL-6 by 50% and 46% combined with carbachol (10 µM), respectively and does not cause any significant reduction in pro-inflammatory cytokines |
|---|---|---|
| In Vivo | Rivastigmine (S-Rivastigmine; 0.5-2.5 mg/kg; IP; 60 min before the tests) significantly and dose-dependently improved the behavioral impairments caused by Aluminum (HY-B1521) | |
| Animal model | Male Wistar albino rats weighing 190–240 g (90 days old) | |
| Dosages | 0.5, 1, 1.5 and 2.5 mg/kg | |
| Administration | IP; single dose |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9946 mL | 19.9728 mL | 39.9457 mL | 79.8913 mL |
| 5mM | 0.7989 mL | 3.9946 mL | 7.9891 mL | 15.9783 mL |
| 10mM | 0.3995 mL | 1.9973 mL | 3.9946 mL | 7.9891 mL |
| 20mM | 0.1997 mL | 0.9986 mL | 1.9973 mL | 3.9946 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.