RG7834 S-isomer

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1250	In Stock
500mg	$2250	In Stock
1g	$3375	In Stock

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Cat #: V3656 CAS #: 2072057-17-9 Purity ≥ 98%

Description: RG7834 S-isomer, also known as RO 7020322 is the S-enantiomer of RG7834 (RO-7020322) which is a novel, potent and orally bioavailable inhibitor of HBV viral gene expression which blocks viral antigen and virion production. RG7834 is highly selective for HBV, and has a unique antiviral profile that is clearly differentiated from nucleos(t)ide analogues. RG7834 (also known as RO 7020322) is a novel, potent, highly selective and orally bioavailable HBV inhibitor which potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively in dHepaRG Cells. RG7834 is a novel oral HBV viral gene expression inhibitor that blocks viral antigen and virion production. RG7834 has a unique antiviral profile that is clearly differentiated from nucleos(t)ide analogues.

References: Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	401.46
Molecular Formula	C22H27NO6
CAS No.	2072057-17-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C(C1=CN2[C@H](C(C)C)CC3=CC(OCCCOC)=C(OC)C=C3C2=CC1=O)O
Synonyms	RO7020322; RO 7020322; RO-7020322;RG7834; RG 7834; RG-7834

Protocol	In Vitro	RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.
	In Vivo	RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice.
	Animal model	HBV-infected human liver chimeric uPA-SCID mice
	Dosages	4 mg/kg
	Administration	Twice daily for 21 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4909 mL	12.4545 mL	24.9091 mL	49.8182 mL
5mM	0.4982 mL	2.4909 mL	4.9818 mL	9.9636 mL
10mM	0.2491 mL	1.2455 mL	2.4909 mL	4.9818 mL
20mM	0.1245 mL	0.6227 mL	1.2455 mL	2.4909 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.