Resmetirom (MGL-3196)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | In Stock |
| 500mg | $1480 | In Stock |
| 1g | $2220 | In Stock |
: Cat #: V3244 CAS #: 920509-32-6 Purity ≥ 98%
Description: Resmetirom (formerly known as MGL-3196, MGL 3196) is a novel, highly potent and selective agonist of the thyroid hormone receptor β (THR-β) with EC50 value of 0.21 μM.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 435.22 |
|---|---|
| Molecular Formula | C17H12Cl2N6O4 |
| CAS No. | 920509-32-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 30 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O |
| Synonyms | VIA 3196; VIA3196; VIA-3196; MGL-3196; MGL 3196; MGL3196; Resmetirom |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2977 mL | 11.4884 mL | 22.9769 mL | 45.9538 mL |
| 5mM | 0.4595 mL | 2.2977 mL | 4.5954 mL | 9.1908 mL |
| 10mM | 0.2298 mL | 1.1488 mL | 2.2977 mL | 4.5954 mL |
| 20mM | 0.1149 mL | 0.5744 mL | 1.1488 mL | 2.2977 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.