Reboxetine mesylate (FCE20124; PNU155950E)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $625 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V2433 CAS #: 98769-84-7 Purity ≥ 98%
Description: Reboxetine (also known as PNU 155950E; Trade name: Edronax) is a selective norepinephrine reuptake inhibitor with Ki of 8.2 nM and antidepressant activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 409.5 |
|---|---|
| Molecular Formula | C19H23NO3.CH4O3S |
| CAS No. | 98769-84-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 82 mg/mL (200.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 82 mg/mL (200.2 mM) | |
| SMILES Code | CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3.CS(=O)(=O)O |
| Synonyms | PNU 155950E; PNU155950E; PNU-155950E; FCE-20124 mesylate; PNU-155950E mesylate; FCE 20124 mesylate; PNU 155950E mesylate; FCE20124 mesylate; PNU155950E mesylate; Reboxetine mesilate; Reboxetine; Edronax; Reboxetine mesylate; Vestra (TN); AC1L2RIX; AC1Q6WCV; DSSTox_CID_25690; DSSTox_RID_81062; DSSTox_GSID_45690. |
| Protocol | In Vitro | Reboxetine mesylate has weak affinity for muscarinic, histaminergic H1, adrenergic α1, and dopaminergic D2 receptors |
|---|---|---|
| In Vivo | Reboxetine mesylate (30 mg/kg; i.p.) significantly decreases the immobility time in the mice depression models | |
| Animal model | Harlan-bred, male CF-1 mice (18-20 g), depression models | |
| Dosages | 3 mg/kg, 30 mg/kg | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4420 mL | 12.2100 mL | 24.4200 mL | 48.8400 mL |
| 5mM | 0.4884 mL | 2.4420 mL | 4.8840 mL | 9.7680 mL |
| 10mM | 0.2442 mL | 1.2210 mL | 2.4420 mL | 4.8840 mL |
| 20mM | 0.1221 mL | 0.6105 mL | 1.2210 mL | 2.4420 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.