RCGD-423
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $800 | Check With Us |
| 500mg | $1300 | Check With Us |
| 1g | $1950 | Check With Us |
: Cat #: V13636 CAS #: 108237-91-8 Purity ≥ 98%
Description: RCGD-423 is a modulator of gp130 signalling.
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| Molecular Weight (MW) | 331.23 |
|---|---|
| Molecular Formula | C15H11BrN2S |
| CAS No. | 108237-91-8 |
| Synonyms | RCGD-423; RCGD 423; RCGD423; Regulator of cartilage growth and differentiation (RCGD) 423 |
| Protocol | In Vitro | RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair |
|---|---|---|
| In Vivo | RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0191 mL | 15.0953 mL | 30.1905 mL | 60.3810 mL |
| 5mM | 0.6038 mL | 3.0191 mL | 6.0381 mL | 12.0762 mL |
| 10mM | 0.3019 mL | 1.5095 mL | 3.0191 mL | 6.0381 mL |
| 20mM | 0.1510 mL | 0.7548 mL | 1.5095 mL | 3.0191 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.