(R)-Nepicastat HCl [RS-25560-198 HCl]

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1340	Check With Us
500mg	$1950	Check With Us
1g	$2925	Check With Us

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Cat #: V0937 CAS #: 195881-94-8 Purity ≥ 98%

Description: (R)-Nepicastat HCl (R-SYN117; R-SYN-117; R-RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl (RS-25560-197; SYN117; SYN-117; RS25560197), is a selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylases (enzymes catalyzing the transformation of dopamine to norepinephrine) with the potential to treat congestive heart failure.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	331.81
Molecular Formula	C14H15F2N3S.HCl
CAS No.	195881-94-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 66 mg/mL (198.9 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SMILES Code	S=C1N([C@H]2CC3=C(C(F)=CC(F)=C3)CC2)C(CN)=CN1.[H]Cl
Synonyms	RS-25560-198 HCl; RS-25560 198 HCl; RS 25560-198 HCl; RS25560-198 HCl

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0138 mL	15.0689 mL	30.1377 mL	60.2755 mL
5mM	0.6028 mL	3.0138 mL	6.0275 mL	12.0551 mL
10mM	0.3014 mL	1.5069 mL	3.0138 mL	6.0275 mL
20mM	0.1507 mL	0.7534 mL	1.5069 mL	3.0138 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.