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| Size | Price | Stock |
|---|---|---|
| 250mg | $680 | Check With Us |
| 500mg | $980 | Check With Us |
| 1g | $1470 | Check With Us |
: Cat #: V0038 CAS #: 545380-34-5 Purity ≥ 98%
Description: QNZ (also known as EVP-4593 or CAY-10470), a quinazoline derivative, is a novel and potent NF-κB inhibitor, which shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in human Jurkat T cells, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 356.42 |
|---|---|
| Molecular Formula | C22H20N4O |
| CAS No. | 545380-34-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 5 mg/mL warming (14.0 mM)r |
| Water:<1 mg/mL (slightly soluble or insoluble)r | |
| Ethanol: <1 mg/mL (slightly soluble or insoluble) | |
| Solubility In Vivo | 0.5% hydroxyethyl cellulose: 30 mg/mL |
| SMILES Code | NC1=CC2=C(N=CN=C2NCCC3=CC=C(OC4=CC=CC=C4)C=C3)C=C1 |
| Synonyms | QNZ; EVP4593; EVP 4593; EVP-4593; CAY10470; CAY-10470; CAY 10470; |
| Protocol | In Vitro | QNZ (Compound 11q) has a suppressing effect of the NF-κB mediated-inflammatory response. QNZ inhibits edema formation dose-dependently. |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8057 mL | 14.0284 mL | 28.0568 mL | 56.1136 mL |
| 5mM | 0.5611 mL | 2.8057 mL | 5.6114 mL | 11.2227 mL |
| 10mM | 0.2806 mL | 1.4028 mL | 2.8057 mL | 5.6114 mL |
| 20mM | 0.1403 mL | 0.7014 mL | 1.4028 mL | 2.8057 mL |
| Quality Control Documentation |
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This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.