Prucalopride (R-108512, R-93877)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$550	Check With Us
5g	$1650	Check With Us
10g	$2475	Check With Us

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Cat #: V1036 CAS #: 179474-81-8 Purity ≥ 98%

Description: Prucalopride (Motegrity; R-108512; R 108512; Resolor; Resotran; R108512; Prudac), a novel enterokinetic compound and the first representative drug of the benzofuran class of laxatives, is a selective and high affinity 5-HT (serotonin) receptor agonist with Kis of 2.5 nM and 8 nM for 5-HT4A and 5-HT4B receptor, respectively.

References: Chen M, et al. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Hum Exp Toxicol. 2020 Feb;39(2):173-181.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	367.87
Molecular Formula	C18H26ClN3O3
CAS No.	179474-81-8
Storage	-20℃ for 3 years in powder formrrrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 60 mg/mL (163.1 mM)rrrr
	Water: <1 mg/mLrrrr
	Ethanol: 38 mg/mL (103.3 mM)
Solubility In Vivo	ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1
Synonyms	R-93877; R 93877; R93877; trade names: Motegrity; Resolor; Resotran; R-108512; R 108512; R108512

Protocol	In Vitro	Prucalopride (10 µM; 24, 48, 72 h) shows anti proliferative activity in A549 cells. Prucalopride induces autophagy and apoptosis, decreases the expression of the phosphorylated protein kinase B (AKT) and mammalian target of rapamycin (mTor) in A549/A427 cells

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7184 mL	13.5918 mL	27.1835 mL	54.3670 mL
5mM	0.5437 mL	2.7184 mL	5.4367 mL	10.8734 mL
10mM	0.2718 mL	1.3592 mL	2.7184 mL	5.4367 mL
20mM	0.1359 mL	0.6796 mL	1.3592 mL	2.7184 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.