GSK429286A (also known as RHO15; GSK 429286A; RHO-15; GSK-429286A) is a potent, orally bioactive, and selective inhibitor of ROCK1/2 with antihypertensive effects.

Ripasudil HCl dihydrate (formerly K-115; K-115; trade name: Glanatec), the hydrochloride salt and hydrated form of ripasudil, is a ROCK1/2 inhibitor with antihypertensive effects.

PD0166285 (PD-0166285) is a novel and potent Wee1 and Chk1 inhibitor with anticancer activity and enzymatic activity at nanomolar concentrations (IC50s of 24 and 72 nM for WEE1 and Myt1, respectively).

ZINC00881524 is a novel, potent and selective ROCK inhibitor.

Y-39983 HCl (also called Y-33075) is a novel, potent and selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6 nM, 0.42 μM and 0.81 μM for ROCK, PKC and CaMKII, respectively.

RKI-1447 (ROCK Inhibitor XIII; RKI 1447; RKI1447) is a potent small molecule inhibitor of ROCK1 and ROCK2 with potential antitumor activities against breast cancer.

Wogonin (Vogonin), a naturally occurring and pharmacologically-active flavonoid found in plants, has been reported to exhibit anticancer effects against various cancer cell types such as osteosarcoma, leukemia, breast cancer and glioma.

Y-27632 is a potent and selective inhibitor of ROCK1 (p160ROCK) with IC50 of 140 nM in a cell-free assay, it exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

RK-33 is a potent and first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Thiazovivin (TZV) is a novel, selective, and cell-permeable small molecule ROCK (Rho-associated kinase) inhibitor with an IC50 of 0.5 μM in a cell-free assay.