Y-39983 HCl (Y-33075)
This product is for research use only, not for human use. We do not sell to patients.
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|---|---|
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| 500mg | Get quote |
| 1g | Get quote |
: Cat #: V2559 CAS #: 173897-44-4 Purity ≥ 98%
Description: Y-39983 HCl (also called Y-33075) is a novel, potent and selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6 nM, 0.42 μM and 0.81 μM for ROCK, PKC and CaMKII, respectively.
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| Molecular Weight (MW) | 353.25 |
|---|---|
| Molecular Formula | C16H18Cl2N4O |
| CAS No. | 173897-44-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 64 mg/mL (199.8 mM)r |
| Water: 14 mg/mL (43.71 mM)r | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Saline: 30 mg/mL |
| Synonyms | Y-39983 2HCl; Y 39983 2HCl; Y39983 2HCl; Y-39983 diHCl; Y39983 diHCl; Y 39983 diHCl; Y-33075 2HCl; Y 33075 2HCl; Y33075 2HCl. |
| Protocol | In Vitro | Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC50 of 3.6 nM. Y-33075 also inhibits PKC and CaMKII more potently than Y-27632, and the IC50s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC50s of Y-27632 and Y-33075 for PKC is 82 and 117 times those for ROCK, respectively, whereas the IC50s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively |
|---|---|---|
| In Vivo | In rabbits, Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration. In monkeys, Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8309 mL | 14.1543 mL | 28.3086 mL | 56.6171 mL |
| 5mM | 0.5662 mL | 2.8309 mL | 5.6617 mL | 11.3234 mL |
| 10mM | 0.2831 mL | 1.4154 mL | 2.8309 mL | 5.6617 mL |
| 20mM | 0.1415 mL | 0.7077 mL | 1.4154 mL | 2.8309 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.