E3 ligase Ligand-Linker Conjugates 45comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.

E3 ligase Ligand-Linker Conjugates 46comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.

E3 ligase Ligand-Linker Conjugates 47comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.

MZP-54 is a novel, potent and selective PROTAC-based degrader of BRD3/4 with a Kd of 4 nM for Brd4BD2.

E3 ligase Ligand-Linker Conjugates 43comprises of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker.

E3 ligase Ligand-Linker Conjugates 42comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.

BRD4 degrader AT1 is a novel, potent and highly selective PROTAC-based BRD4 degrader (Kd = 44 nM for Brd4BD2 in cells) with anticancer activity.

PROTAC ER α Degrader-1 is a PROTAC degrader

GMB-475 is a novel and potent degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance.

Gefitinib-based PROTAC 3 is a novel, potent and selective VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).