Acalisib (formerly known as CAL-120; GS-9820) is a novel, potent and highly selective inhibitor of p110δ[the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K)] with anticancer activities.

Quercetin (Sophoretin; NSC-9221; Kvercetin) is a natural flavonoid isolated from various vegetables, fruits and wine.

AS-041164 is a Potent and selective PI3Kγ inhibitor (IC50 = 70 nM).

Pictilisib mesylate (also called GDC-0941 mesylate, Pictrelisib, RG7321 and GNE0941 mesylate) is a potent and orally available inhibitor of PI3Kα/δ (class I phosphatidylinositol 3 kinase) with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold).

GDC-0326 is a novel, potent and selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor with a Ki of 0.2 nM.

CNX-1351 (CNX1351; CNX 1351) is a novel, potent, covalent and selective inhibitor of PI3Kα with anticancer activity.

PWT143, formerly known as ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity.

VS-5584 (also known as SB2343), a purine analog, is a novel, potent and selective small-molecule dual inhibitor of both mammalian target of rapamycin (mTOR) kinase and all class I phosphoinostide 3-kinase (PI3K) isoforms with potential anticancer activity.

Serabelisib (formerly known as INK-1117, MLN-1117, and/or TAK-117) is a potent, selective, and oral bioavailable inhibitor of PI3Kα (phosphoinositide 3-kinase) isoform with IC50 of 21 nmol/L against PI3Kα.

Duvelisib R enantiomer is the R-isomer of Duvelisib (formerly known as IPI-145 and INK1197, trade name: Copiktra) which is an isoquinolinone derivative and a novel potent, oral and selective small-molecule phosphoinositide-3 kinases (PI3K) inhibitor that selectively and potently inhibits two PI3K isoforms, PI3K-δ and PI3K-γ, with half maximal inhibition concentration IC50 of 2.5 nM and […]