ITI-214 is an orally bioavailable, potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.

K-Ras-PDEδ-IN-1 is a novel and potent competitive K-Ras-PDEδ inhibitor.

Propentofylline (HWA285; HWA-285; HWA 285; Karsivan; Hextol; Propentophylline), a xanthine derivative, is a potent phosphodiesterase (PDE) inhibitor with potential neuroprotective activity.

BAY 73-6691 racemate is a novel, potent, selective, and brain penetrant PDE9A (Phosphodiesterase 9) inhibitor.