NSC59984 is a novel and potent activator of p53 with potential anticancer activity.

MI-773 (2’S,3R isomer, SAR405838) is a novel, potent, specific and orally bioavailable small molecule antagonist of MDM2/piro-oxindole HDM2 (Murine double minute 2/human double minute 2) with a Ki value of 0.88 nM.

Pifithrin-β (also known as QB102 and Cyclic-Pifithrin-α) is a novel and potent p53 inhibitor with an IC50 of 23 μM.

Serdemetan (formerly JNJ26854165; JNJ-26854165; JNJ 26854165), originally developed as an activator of p53, is now considered to be a novel, potent and orally bioactive antagonist of Human Double Minute-2 (HDM-2) ubiquitin ligase with antitumor activities.

Kevetrin hydrochloride (also known as thioureidobutyronitrile; 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride), is a water-soluble, small molecule activator of the tumor suppressor protein p53.

RITA (also known as NSC-652287) is a novel and potent inhibitor of p53-HDM-2 protein-protein interaction with potential anticancer activity.

SCH-529074 is a novel,potent and orally active p53 activator.

PK11000 is a novel and potent p53-targeting compound and an alkylating agent with anti-tumor activities through activation of unstable p53 (tumor suppressor p53).

CBL0137 HCl, the hydrochloride salt of CBL-0137 (formerly Curaxin 137 or CBL 0137), is an inhibitor of the histone chaperone, FACT (facilitates chromatin transcription complex).

Tenovin-6 is an analog of tenovin-1 with higher water-solubility and has potential anticancer activity.