SB-334867 HCl (SB-334867A; SB334867; SB 334867), the hydrochloride salt of SB-334867, is a novel, non-peptide, selective orexin-1 (OX1) receptor antagonist with the potential for treating sleeping disorders.

TCS-OX2-29 HCl, the hydrochloride salt of TCS-OX229, is a non-peptide and selective OX2 receptor antagonist (IC50 = 40 nM) with potential use in the treatment of insomnia.

MK-1064 (MK1064) is a novel, potent, selective and orally bioavailable antagonist of Orexin OX2 Receptor (OX2R), with the potential to be used for the treatment of insomnia.

Seltorexant (also known as MIN-202 and JNJ-42847922), is a novel, potent and selective orexin-2 receptor antagonist. It can promote sleep in various species and is under development for the treatment of insomnia and major depressive disorder.