CA-327 is a novel potent, orally available, small molecule and dual inhibitor of TIM3 and PD-L1 with potential anticancer activities. In addition to PD-1, there are several other checkpoints involved in the modulation of immune responses to tumor cells. One such checkpoint is T-cell immunoglobulin and mucin domain containing protein-3 (TIM3), which shares some structural […]

Pembrolizumab (formerly known as MK-3475 and lambrolizumab, trade name Keytruda) is a humanized antibody and PD-1/PD-L1 inhibitou used in cancer immunotherapy. It is an IgG4 isotype antibody that blocks a protective mechanism of cancer cells and thereby, allows the immune system to destroy them. It targets the programmed cell death protein 1 (PD-1) receptor of […]

Ipilimumab (trade name Yervoy; also known as MDX-010; BMS-734016) is a fully human monoclonal IgG1κ antibody against the cytotoxic T-lymphocyte antigen-4 (CTLA-4), which is an immune-inhibitory molecule expressed in activated T cells and in suppressor T regulatory cells. Ipilimumab is a monoclonal antibody that works to activate the immune system by targeting CTLA-4, a protein […]

LBQ-657 sodium (also known as Sacubitrilat) is a novel and potent endopeptidase inhibitor.

Taminadenant HCl (PBF509; NIR178) is a novel potent and oral non-xhantine non-furan A2AR (adenosine) antagonist with the potential to be used as a pro-dopaminergic drug for PD management. PBF509 was shown to be a highly potent ligand at the human A2AR, since it antagonized A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of […]

Rituximab (trade name: Rituxan; Anti-Human CD20 type I, Chimeric Antibody) is an anti-CD20 chimeric monoclonal antibody (mAb) used to treat certain autoimmune diseases and types of cancer such as B-cell malignancies as well as organ transplantation. Rituximab is used for non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura, pemphigus vulgaris, […]

ADU-S100 (formerly known as MIW-815; MIW815; ML RR-S2 CDA), a cyclic dinucleotide, is a novel and potent agonist of STING (Stimulator of Interferon Genes) with immunomodulatory and anticancer activities. ADU-S100 has the potential to be used in cancer immunotherapy. It elicits potent and durable anti-tumor immunity when administered intratumorally in pre-clinical syngeneic tumor models. As […]

Syn-Ake is a novel biomimetic peptide and a muscarinic acetylcholine receptor antagonist. It smoothens expression lines by topical application. It mimics the activity of Waglerin-1, a natural occurring peptide found in temple viper venom which has a strong ability to relax muscle contraction.

NSC 409012 is an active compound.

BFMO can be used for As removal from water containing high concentrations of Fe(II) and Mn(II).