ADU-S100 | CAS 1638241-89-0

ADU-S100

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Cat #: V3938 CAS #: 1638241-89-0 Purity ≥ 98%

Description: ADU-S100 (formerly known as MIW-815; MIW815; ML RR-S2 CDA), a cyclic dinucleotide, is a novel and potent agonist of STING (Stimulator of Interferon Genes) with immunomodulatory and anticancer activities. ADU-S100 has the potential to be used in cancer immunotherapy. It elicits potent and durable anti-tumor immunity when administered intratumorally in pre-clinical syngeneic tumor models. As of 2018, it has entered phase I clinical trials for the treatment of cancer. Clinical candidate STING agonist ADU-S100 (S100) is used in an intratumoral dosing regimen optimized for adaptive immunity to uncover requirements for a T cell-driven response compatible with checkpoint inhibitors (CPIs).

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	736.52
Molecular Formula	C20H24N10Na2O10P2S22
CAS No.	1638241-89-0
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >10 mM
	Water: N/A
	Ethanol: N/A
SMILES Code	O[C@@H]1[C@H](O[C@H]([C@@H]1O2)N3C4=C(N=C3)C(N)=NC=N4)CO[P@@](S)(O[C@H]5[C@H]([C@@H](O[C@@H]5CO[P@]2(S)=O)N6C7=C(N=C6)C(N)=NC=N7)O)=O.[Na+].[Na+]
Synonyms	ADU-S100; ML RRS2 CDA; MIW815; ADU S100; ML RR S2 CDA; MIW-815; ADUS100; ML RR-S2 CDA sodium salt; MIW 815

Related Biological Data

ML RR-S2 CDA promotes immune-mediated tumor rejection. Cell Rep. 2015 May 19;11(7):1018-30.

Modified CDNs potently activate STING and signal through all human STING allelic variants. Cell Rep. 2015 May 19;11(7):1018-30.

Synthetic CDN modifications significantly improve anti-tumor efficacy in established B16 tumors. Cell Rep. 2015 May 19;11(7):1018-30.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3577 mL	6.7887 mL	13.5774 mL	27.1547 mL
5mM	0.2715 mL	1.3577 mL	2.7155 mL	5.4309 mL
10mM	0.1358 mL	0.6789 mL	1.3577 mL	2.7155 mL
20mM	0.0679 mL	0.3394 mL	0.6789 mL	1.3577 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.