ARN 077 (ARN-077) is a novel, potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats. Topical administration of ARN077 attenuated, in a dose-dependent manner, heat hyperalgesia and […]

MEK-IN-1 is a novel and potent MEK inhibitor disclosed in patent WO2008076415A1.

ARV-471 (ARV471) is a first-in-class, selective and orally bioavailable PROTAC-based Estrogen Receptor (AR) degrader. As a PROteolysis-TArgeting Chimera (PROTAC) small molecule, it induces degradation of wildtype and mutant ER. ARV-471 displays superior ER degradation and antitumor activity compared to fulvestrant in endocrine sensitive and resistant xenograft models. ARV-471 also demonstrated robust ER degradation in paired […]

CCR6 antagonist 1 is a CCR6 antagonist with the potential to be used in autoimmune diseases, e.g. inflammatory bowel diseases (IBDs).

Sudan Black B is a diazo-based dye/coloring agent used to assess myelin repair in demyelinating diseases. It is fat-soluble and can be used as a histochemical stain for staining of neutral triglycerides and lipids.

Fast Red Violet LB is a dye that can be used for staining TRAP (tartrate resistant acid phosphatase). It can also be used for staining and measuring of alkaline phosphatase (ALP) activity.

P2Y2R/GPR17 antagonist 1, P2Y2R and GPR17 antagonist

Fluridone is an herbicide acting as an inhibitor of abscisic acid (ABA) biosynthesis. Fluridone suppresses the expression of AchnFAR and TF genes and reduces the formation of primary alcohol. It inhibits phytoene desaturase (Ki = 0.03 µM), an enzyme involved in carotenoid biosynthesis.

C021 (C-021; CCR4 antagonist) is a novel and potent CCR4 antagonist with anti-inflammatory activity. It exhibits IC50 of 0.039 and 0.14 μM for inhibition of chemotaxis in mouse and human, respectively.

GS-441524 is an active metabolite of Remdesivir (GS-5734; Veklury) which is an FDA approved drug for treating the 2019-nCoV (COVID-19 pandemic, CoronaVirus) infections. GS-441524 is a novel, potent FIP (feline infectious peritonitis) virus inhibitor with an EC50 of 0.78 μM. GS-441524 potently FIP virus in tissue culture and experimental cat infection studies. GS-441524 is a […]