KRAS G12C inhibitor 5 is a novel and potent inhibitor of KRAS. The compound inhibits KRAS G12C which is a well-validated driver mutation present in approximately 14% of NSCLC adenocarcinoma patients and 5% of CRC patients. Patients with KRAS mutation-positives cancers generally have a poor prognosis and resistant to standard therapies.

Azadiradione is a natural product

CPFX4158 is a novel mannose analog that can be potentially used in transgenic humanized-CEACAM6 mouse as antibacterial agent.

GW406381 is a novel, potent and highly selective cyclooxygenase-2 (COX-2) inhibitor that is able to attenuate spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. GW406381, as a novel COX-2 inhibitor, has a potential for the treatment of acute migraine. GW406381 has been shown to be effective in animal models of central […]

GNE-8505 is a novel, potent and orally bioavailable inhibitor of Dual leucine zipper kinase (DLK). Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these processes remain largely undefined. Dual leucine zipper kinase (DLK) is an essential regulator of the progressive neurodegeneration that occurs in […]

WU-07047 (WU07047) is a novel and potent inhibitor of Gαq/11, it is a simplified analog of the selective Gαq/11 inhibitor YM-25489.

Fiacitabine(also known as NSC 382097; DRG-0077) is a novel, potent and selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. Fiacitabine is a pyrimidine nucleoside analog reported to elicit potent anti-VZV activity both in vitro and in vivo. Fiacitabine has potent […]

CM037 is a novel, potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor which acts by binding within the aldehyde binding pocket of ALDH1A1 in a competitive mode of inhibition.

GW7604, the metabolite of GW5638, is a novel, potent and high affinity estrogen receptor (ER) antagonist (also called antiestrogen).

Tetrahydrouridine, a synthetic pyrimidine nucleoside analog, is novel and potent inhibitor of cytidine deaminase (CDA) with biomodulating activity, it competitively blocks the enzyme’s active site more effectively than intrinsic cytidine. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2′-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor […]