AMP-PNP (Adenylyl-imidodiphosphate tetralithium), a non-hydrolysable analogue of ATP, is a novel Kir6 (KATP) channel blocker that inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

SX-3228 is a novel and potent benzodiazepine1 (BZ1) receptor agonist

Palbinone is a novel and potent terpenoid

Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside is a novel and potent flavonoid

Mal-PEG2-VCP-Eribulin is a drug-linker conjugate composed of Mal-PEG2-VCP (an ADC linker) and Eribulin (a highly potent mitotic/tubulin inhibitor used a warhead in ADC). Eribulin (E7389; E-7389; trade name Halaven) is microtubule targeting agent (MTA) that has been approved for use in the treatment of metastatic breast cancer. Mal-PEG2-VCP-Eribulin is used in the construction of antibody […]

PC Methyltetrazine-PEG4-NHS carbonate ester is a novel and potent PROTAC linker

(Z)-MDL 105519 is a novel and potent bioactive compound

Amine-PEG-CH2COOH (MW 5000) is a novel and potent PROTAC linker

GNE-064, soluble inhibitor of the SMARCA4, SMARCA2 and PBRM1 bromodomains 5

HDACs/mTOR Inhibitor 1 is a novel and potent dual inhibitor of Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) with potential anticancer activity.