Mal-PEG2-VCP-Eribulin

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V31666 CAS #: 2130869-18-8 Purity ≥ 99%

Description: Mal-PEG2-VCP-Eribulin is a drug-linker conjugate composed of Mal-PEG2-VCP (an ADC linker) and Eribulin (a highly potent mitotic/tubulin inhibitor used a warhead in ADC). Eribulin (E7389; E-7389; trade name Halaven) is microtubule targeting agent (MTA) that has been approved for use in the treatment of metastatic breast cancer. Mal-PEG2-VCP-Eribulin is used in the construction of antibody drug conjugates-ADC.

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Molecular Weight (MW)	1374.57
Molecular Formula	C₇₀H₉₉N₇O₂₁
CAS No.	2130869-18-8

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.7275 mL	3.6375 mL	7.2750 mL	14.5500 mL
5mM	0.1455 mL	0.7275 mL	1.4550 mL	2.9100 mL
10mM	0.0728 mL	0.3638 mL	0.7275 mL	1.4550 mL
20mM	0.0364 mL	0.1819 mL	0.3638 mL	0.7275 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.