BTB-1 is a novel, potent and the first small molecule inhibitor of the mitotic motor protein Kif18A.

TN-16 (TN16; NSC-239274) is a potent tubulin inhibitor (antitubulin/antimitotic agent) with anticancer activity.

Ixabepilone (formerly known as azaepothilone B and BMS-247550; Trade name: Ixempra) is a potent and orally bioavailable microtubule-stabilizing agent for the treatment of cancer. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. BMS-247550 (ixabepilone), the lactam […]

BNC105 is a potent benzofuran-based tubulin polymerization inhibitor and also a vascular disrupting agent (VDA) prodrug with potential anti-vascular and anticancer activities.

Taltobulin trifluoroacetate (HTI-286; HTI286; SPA-110; SPA110), the trifluoroacetate salt of taltobulin, is an nalogue of Hemiasterlin, acting as a tubulin inhibitor and used as an ADC cytotoxin (warhead).

Maytansine (maitansine; NSC153858) is a cytotoxic antitubulin agent and an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata.

Monomethyl auristatin F (MMAF) sodium is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A.

Epothilone D (formerly known as KOS 862; KOS-862; desoxyepothilone B) is a potent microtubule stabilizing agent that has high anticancer activity.

Ansamitocin P-3 (Maytansinol isobutyrate; NSC-292222; Antibiotic C 15003P3) is a potent microtubule/antimitotic inhibitor used as an warhead of ADC (antibody drug conjugate).

Demecolcine (Colcemid), a colchicine analog, is a potent microtubule polymerization inhibitor / mitotic inhibitor /depolymerizing anti-tubulin agent with anticancer activity.