LY 341495 is a novel, potent and selective orthosteric antagonist of the metabotropic glutamate receptors (mGluR) with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.

FPTQ is novel and potent antagonist of mGluR1 (metabotropic glutamate receptor subtype 1) with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.

VU6012962 is a novel, potent, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM.

JNJ16259685 (JNJ-16259685) is a novel, potent, selective and non-competitive antagonist of mGlu1 receptor with IC50 of 19 nM.

PHCCC is a potent PAM (positive allosteric modulator) of mGluR4 and a Group I metabotropic glutamate receptor antagonist with IC50 of ~ 3 μM.

AZD-8529 mesylate is a novel, potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 (group II metabotropic glutamate receptors) with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

AZD-8529 is a novel, potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 (group II metabotropic glutamate receptors) with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

FITM is a novel, potent and negative allosteric mGlu1 inhibitor (Ki of 2.5 nM. ).

Lu AF32615 is a brain-penetrant positive allosteric modulators (PAMs) of the mGlu4 receptor.

Ro 67-7476 is a novel and selective positive allosteric modulator of mGlu1 receptors.