BMS-986020 (also known as AM152 and AP-3152 free acid) is a novel, potent and selective LPA1 (lysophosphatidic acid) antagonist.

CYM-5541 (also known as ML249) is a potent, selective, full, and allosteric agonist of the S1P3 (Sphingosine 1-phosphate) receptor with EC50 in the range of 72 to 132 nM.

Cenerimod (ACT-334441) is a potent and orally bioavailable immunomodulator, which exhibited an EC50 of 2.7 nM.

AM095 free acid is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively.

SEW2871 (SEW-2871) is a S1P1 agonist (sphingosine-1-phosphate type 1 receptor agonist) with EC50 of 13.8 nM.

ONO-7300243 (ONO 7300243, ONO7300243) is a novel, potent and selective antagonist of LPA1(Lysophosphatidic Acid Receptor) with an IC50 of 160 nM.

Etrasimod (formerly APD334; APD3-34) is a potent, centrally bioavailable, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases.

CYM-5442 is anovel, potent and highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist which reduces the severity of acute GVHD by inhibiting macrophage recruitment.