Peramivir Trihydrate (also known as BCX-1812, RWJ-270201, S-021812; trade name Rapivab) is a trihydrate form of the antiviral agent peramivir which is a transition-state analogue and a specific influenza viral neuraminidase inhibitor approved for the treatment of influenza. It inhibits with neuraminidase an IC50 of median 0.09 nM. Peramivir protects mice against severe disease outcomes […]
Peramivir (formerly RWJ270201; BCX1812; S021812; Rapivab; Rapiacta; Peramiflu) is an antiviral agent acting as a neuraminidase inhibitor and has been approved for treating influenza.
Umifenovir (trade name Arbidol) HCl, the hydrochloride salt of umifenovir, is a broad-spectrum antiviral drug that blocks viral fusion, and was approved for use in Russia and China for the treatment of influenza and other respiratory viral infections. Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent […]
Umifenovir (trade name Arbidol) is a broad-spectrum antiviral drug that inhibits viral fusion, and has been approved for use in Russia and China for the treatment of influenza and other respiratory viral infections.
KIN1148 is a small-molecule agonist of the IRF3 (RIG-I-like receptor) pathway and a novel adjuvant therapy of influenza vaccine that is able to enhance the efficacy of flu vaccine. It induces the dose-dependent nuclear translocation of IRF3 in PH5CH8 cells and specific activation of IRF3- responsive promoters. KIN1148 also elicits greater induction of endogenous IRF3-dependent […]
Coumarin is a novel and potent fragrant organic chemical compound.
Glycitin is a novel and potent TAS2R agonist.
Nitazoxanide D4 (NTZ D4; NSC-697855 D4) is the deuterium labeled (deurated) form of Nitazoxanide, which is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent with IC50 for canine influenza virus ranges from 0.17 to 0.21 μM. Nitazoxanide was approved for treating human protozoan infections. Nitazoxanide reduces parasite growth in cell culture by more than 90% […]
Beta-Cyclodextrin is a novel and potent cyclic heptamer/cyclic oligosaccharide produced from starch via enzymatic conversion.
KIN101 (KIN-101) is an isoflavone acting as a RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively.