MPI-5a is a potent and selective inhibitor of HDAC6.
Romidepsin (formerly FK-228, FR-901228, Depsipeptide, NSC-630176; trade name Istodax) is a novel, potent and naturally occuring bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with potential anticancer activity.
Rocilinostat (formerly Ricolinostat; ACY-1215), an investigational drug, is a potent, orally bioavailable and selective HDAC6 inhibitor with potential anticancer activity.
Tubastatin A HCl, the hydrochloride salt of Tubastatin A (also known as TubA, AG-CR-13900), is a tubacin analog that acts as a potent and specific inhibitor of histone deacetylase 6 (HDAC6) with potential antitumor, neuroprotective and anti-inflammatory activities. It exhibits the highest selectivity (>1,000-fold) for inhibiting HDAC6 over other HDAC isoforms excluding HDAC8 for which […]
Resminostat (formerly RAS-2410; 4SC-201) is a potent inhibitor of classes I and II HDACs (histone deacetylases) such as HDAC1/3/6 with potential anticancer activity.
Domatinostat HCl (formerly 4SC202; 4SC-202), the hydrochloride salt of Domatinostat, is a class I HDAC inhibitor (HDACi) with potential anticancer activity.
Mocetinostat (formerly MGCD-0103 or MG-0103), is a potent, benzamide-based and orally bioavailable Class I-selective inhibitor of human histone deacetylases (HDAC) with potentianl anticancer activities.
Scriptaid (formerly GCK1026; Scriptide) is a novel and potent histone deacetylase (HDAC) inhibitor with potential anticancer activity. It shows potent anti-proliferative activity in vitro against various cancer cells such as Ishikawa endometrial and SK-OV-3 ovarian cancer cell lines. It can also sensitize the activity of antivirals with a potential for treating epstein-barr virus (EBV)-associated lymphomas.
TMP195 (TMP-195) is a first-in-class and selective inhibitor of class IIa histone deacetylase (HDAC) with anticancer and immunomodulatory effects.
Tubacin (known also as tubulin acetylation inducer) is a specific HDAC6 (histone deacetylase 6) inhibitor with potential anticancer activity.